Role of H2S Supplementation on Burn Wound Healing and Molecular Chaperones

Treatment of non-healing burn injuries is a major challenge for the current scientific research. Hydrogen sulfide (H2S) an endogenous gasotransmitter, which regulates redox homeostasis and cytoprotection during pathophysiological conditions. Similarly, heat shock proteins (HSPs) are molecular chaperones, also confer wound repair process. Notably, role H2S as regulator HSPs healing still elusive. The present study investigated effects supplementation on chaperones full-thickness, third-degree in experimental rats. animals were treated with sodium hydrosulphide (NaHS) donor (5 mg/kg body weight, intraperitoneal) daily 10 days prior to burn-induction continued till fifth-day post-wounding. Histopathological analysis (Masson’s trichrome) revealed enhanced evident by increased collagen fiber deposition, cellular proliferation re-epithelialisation NaHS administered group compared control. Furthermore, immunoblot analyses demonstrated significantly protein expression chaperons viz. HSP90, HSP70, HSP27, GRP78 Therefore, signifies that upregulates levels could facilitate tissue process accelerates healing.